The Sarah Silverman Program: Season 2: Vol.
Sarah Silverman - Simple English Wikipedia, the free encyclopedia. Sarah Kate Silverman (born December 1, 1. Americanstand- up comedienne, writer, actress, singer, voice actress, and musician. Although usually credited as Sarah Silverman, she is sometimes credited by her nickname, Big S. Her satirical comedy addresses social taboos and controversial topics such as racism, sexism, and religion. Retrieved September 7, 2. Retrieved September 7, 2. The Hollywood Reporter. Retrieved September 7, 2. Retrieved October 9, 2. Sarah Silverman i The Sarah Silverman Program. I januari 2008 var Silverman g! Sarah Silverman is best known for her cutting stand-up comedy routines although her career also includes writing and acting for television and film. Retrieved April 1. Retrieved April 1. Retrieved April 1.
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Basilea and Astellas Update Isavuconazole Phase III Trial in Consultation With FDABASEL, SWITZERLAND- -(Marketwire - 1. Basilea Pharmaceutica AG / Basilea and Astellas update isavuconazole phase III trial in consultation with FDA Processed and transmitted by Thomson Reuters. Post-Authorization Safety Program—Validation of the Clinical Practice Research Datalink for the Study of. MBBS, MRCS, MD (Astellas Pharma Europe. News releases by Astellas Pharma are available here. OAB affects more than 400 million people worldwide.4. They reviewed extensive clinical trial evidence from 7 Phase II / III studies in which over 5,000 patients. A phase II dose-ranging study of mirabegron in patients with overactive bladder. The issuer is solely responsible for the content of this announcement. Basel, Switzerland, November 2. Basilea Pharmaceutica Ltd. Food and Drug Administration (FDA) Basilea and its partner Astellas Pharma Inc. The company confirms the previously communicated timelines for the ongoing phase III program. All- cause mortality, which was one of the secondary study endpoints, will become the primary endpoint of the phase III clinical trial investigating isavuconazole in invasive aspergillosis. The total target number of patients will be around 5. Considering an antimuscarinic treatment for overactive bladder (OAB)? Learn about VESIcare, including clinical study data and access programs for your patients. VESIcare for overactive bladder (OAB) symptoms of urge urinary. Study to Evaluate the Efficacy, Safety, and Tolerability of Mirabegron in Older Adult Subjects With Overactive Bladder (OAB) (PILLAR). Canadian Urological Association Partners with Astellas Pharma Canada, Inc. The objective of the CUA Astellas Research Grant Program is to. The previous primary outcome measure of 'overall response' (clinical, mycological and radiological response) will continue to be assessed in the study as a secondary endpoint. We will continue to assess the overall response as a secondary endpoint to obtain a comprehensive clinical profile of this novel drug. Initiation of first sites is anticipated at year- end or early 2. III results continues to be expected in 2. About isavuconazole. Pre- clinical and clinical data generated to date indicate that isavuconazole has the potential to overcome many limitations of current therapies for the treatment of invasive fungal infections. Isavuconazole is given by intravenous infusion or oral capsules with high oral bioavailability that provides an option for intravenous- oral step- down. The drug has predictable and dose proportional pharmacokinetics that are important to ensure adequate therapeutic drug levels in patients with life- threatening fungal infections. The intravenous dose form has the potential to be given safely to patients with renal impairment. The clinical program includes three international phase III trials with centers in the U. S., Europe and other regions that target respectively, yeast infections (candidemia/invasive Candida infections), mold infections (invasive aspergillosis) and finally rare molds and aspergillosis in renally impaired patients. Earlier this year, an Independent Data Safety Monitoring Board recommended continuation of the phase III clinical trial of isavuconazole for the treatment of invasive Aspergillus infections based on a futility analysis of the first 1. Isavuconazole has been granted fast track designation by the U. S. Food and Drug Administration (FDA). Conference call. Basilea Pharmaceutica Ltd. Participants requesting a digital playback may dial: +4. Europe)+1 (1) 8. 66 4. USA)+4. 4 (0) 2. 07 1. UK)and will be asked to enter the ID 1. About Basilea. Basilea Pharmaceutica Ltd. Its fully integrated research and development operations are currently focused on antibiotics, antifungals and oncology drugs, as well as on the development of dermatology drugs, targeting the medical challenge of resistance and non- response to current treatment options in the hospital and specialty care setting. Basilea is currently marketing Toctino. Furthermore, a phase III clinical program on alitretinoin for the treatment of severe chronic hand eczema is ongoing in the U. S. The company has entered into a global partnership with Astellas Pharma Inc. Full rights to ceftobiprole for the treatment of potentially life- threatening resistant bacterial infections, are being transferred from Cilag Gmb. H International, a Johnson & Johnson company, back to Basilea. About Astellas. Astellas Pharma Inc., located in Tokyo, Japan, is a pharmaceutical company dedicated to improving the health of people around the world through the provision of innovative and reliable pharmaceuticals. Astellas has approximately 1. The organization is committed to becoming a global category leader in urology, immunology & infectious diseases, neuroscience, DM complications & metabolic diseases and oncology. Astellas has discovered a treatment for over- active bladder (OAB), Vesicare. For more information on Astellas Pharma Inc., please visit www. News releases by Astellas Pharma are. Favorable Immunogenicity and Tolerability Observed in Phase I/II Clinical Trialfor. Astellas' Environmental Initiatives Program in Ireland-Construction of Wind Turbine. MARKHAM, ON, April 10, 2013- Astellas introduces Myrbetriq Disclaimer. This communication expressly or implicitly contains certain forward- looking statements concerning Basilea Pharmaceutica Ltd. Such statements involve certain known and unknown risks, uncertainties and other factors, which could cause the actual results, financial condition, performance or achievements of Basilea Pharmaceutica Ltd. Basilea Pharmaceutica Ltd. The owner of this announcement warrants that: (i) the releases contained herein are protected by copyright and other applicable laws; and (ii) they are solely responsible for the content, accuracy and originality of the information contained therein. Source: Basilea Pharmaceutica AG via Thomson Reuters ONE. Amazon.com: huawei wireless modem. Huawei E5330Bs-6 21Mbps 3G Mobile WiFi (3G 850/1900MHz in the Americas, 3G 2100MHz in Europe. HUAWEI E355 3G WiFi Modem Router is one of the best 3G USB modem to work as 3G WiFi Router, supporting 10 users and HSDPA Speed at 21Mbps. Huawei E355 has external. Huawei Mobile WiFi E589 Router. We need to unlock the modem before sending. Switch Network Among 2G/3G/4G; Huawei E589 Screen Indicators. Huawei is a leading global information and communications technology (ICT). Wireless Network; Fixed Network; Cloud Core Network; Carrier Software; IT Infrastructure. 3G 4G WiFi Router,4G LTE Router at lsuntech.com.L-Sun Technology Limited is a High-tech. 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Directly below are three unique ways that you can use to join the effort to protect urban wildlife as well as make some positive additions to urban ecosystems at the same time. Some of these ideas you might be familiar with, and others you might not. In any case, spread the word! Apply to Have Your Property or Neighborhood Designated as an Official Urban Wildlife Sanctuary. No outdoor space you own or live in is too small to use if you would like to participate in the Humane Society’s Urban Wildlife Sanctuary Program. Even your neighborhood or building can apply collectively. The Humane Society will provide you with a variety of educational materials about how to enhance or rehabilitate your land (or even the balcony of your apartment!) into a place that is more hospitable for urban wildlife. Bird feeders, small butterfly gardens, and a variety of plants can be useful food sources, places to rest, and homes for many species of animals. 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Have you ever wanted to be part of a scientific research project? I’m not talking about that trip you made to the science fair when you were 1. I’m talking about citizen science. As more and more members of the public have become interested, the scientific community has caught on and is now utilizing people like YOU to collect real data to help answer actual research questions. Some of these questions can even involve urban wildlife, who are part of one of the most poorly researched ecosystems: cities. Examples of programs you might want to participate in that involve urban wildlife include the Cornell Lab of Ornithology’s numerous citizen science projects to count birds and study their behavior and also a biodiversity monitoring effort for spiders called Spider Webwatch. The Museum of Science in Boston has joined several universities to create a firefly watch program, as their is evidence that fireflies might be disappearing in the U. S. You can set up a study site where you live and collect data for any of these projects, as well as many others. Some great websites for finding information about citizen science projects are Cornell’s Citizen Science Central and also Terrie Miller’s extensive page that is devoted to the subject. Hopefully one or several of these ways to help protect urban wildlife appeals to you. And wouldn’t it be great if someone made a green roof on top of their home, certified it as an urban wildlife sanctuary, and then used it for scientific research? Maybe it could be you! If you have more suggestions for other readers about programs, tips, or efforts to help protect urban wildlife, please don’t hesitate to mention them in the comments section. Thanks! Read More About How Urban Wildlife is Affected By Light Pollution and Green Roofs on the Green Options Network: Chicago Suburb Preserves Night Sky with Innovative Light Ordinance. Cities Need to Offer Incentives for Building Green Roofs. Landscape Architecture Organization Unveils New Green Roof for Headquarters. Photo Credits: All photos are from Flickr under Creative Commons licenses. Keep up to date with all the most interesting green news on the planet by subscribing to our (free) Planetsave newsletter. Tags: Animals, citizen science, Cornell Lab of Ornithology, Firefly Watch Program, green roof, Humane Society, Spider Webwatch, urban wildlife, Urban Wildlife Sanctuary Program. About the Author. Levi Novey Levi Novey is a conservation professional who has received a bachelor's degree in History from Tufts University and a master's degree in Conservation Social Sciences from the University of Idaho. He worked for the U. S. National Park Service for 1. Natural Resource Inventory and Monitoring Network that serves 9 parks. He has authored several scholarly papers as well as several guidebooks to U. S. He currently lives in Peru, with his wife Alicia, and their daughter Coral. Refrigerator Repair FAQ . 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For troubleshooting, feature requests, and general help, contact Customer Support at. Make sure to include details on your browser, operating system, Visual Light. Box version, and a link to your page. Create your gallery in Visual. Light. Box and publish it on a local drive in any test folder. Open index. html file from the saved folder in any text editor. Copy code for the HEAD section and paste it inside the HEAD/BODY section of you own webpage, for example. Copy code for the BODY section and paste it inside the Body section of you own webpage in the place where you want to have a. Copy 'data' folder with images and thumbnails and 'engine' folder with . What do I do? A. Free edition of Visual Lightbox doesn't allow you to remove our watermark. Register your Visual Lightbox application at first. After the registration you can remove watermarks. Open Gallery- > Properties- > Templates: Watermark. Click to disable this option or use your own watermark. So the gallery loads externally? A. You should start the gallery on. Click: 1) Add the following function into the < head> tag. Just change the following code. Please see the previous question (step 4). Add the following parameter to show thumbnail that you want to display on the page. Can you please help? A. You can align Visual. Light. Box thumbnails in the same way as any other element of your page. Try add Visual. Lightbox BODY section into DIV container or into TABLE, set container's sizes and use the alignment that you need. How can I do this? A. Open engine\css\visuallightbox. Insert a gallery in the usual way. Bukkit. The Sculptor plugin adds a handful of tools that can be used make quick changes and fixes to your landscape. V shaped valley./sculpt bind valley 2 1. Using the landscape from the image above and the valley tool. 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The complete manual specific stretching. The complete manual specific stretching. Download autostretching the complete manual of specific stretching and many other ebooks related with autostretching the complete manual of specific stretching and pdf. Comparison of manual therapy and exercise therapy in osteoarthritis of the hip: A randomized clinical trial - Hoeksma - 2. Arthritis Care & Research. INTRODUCTIONOsteoarthritis (OA) is a common cause of disability. OA is characterized by progressive loss and degeneration of articular cartilage, sclerosis of the subschondral bone, and formation of osteophytes (1–3). These changes often lead to pain, loss of mobility and muscle function, restriction in activities of daily living, and decreased quality of life. In clinical practice, there is a variety of conservative treatment methods available for patients with OA of the hip, including manual therapy and exercise therapy (4). Manual therapy includes manipulation and stretching techniques. Manual therapy is particularly aimed at the improvement of elasticity of the joint capsule and the surrounding muscles (5). Manual therapy is provided by physical therapists (or medical doctors) with a special training in manual therapy. Exercise therapy includes both active and passive exercises (6–9). Exercise therapy aims at improvement of muscle function, increase of joint range of motion, decrease of pain, and increase of walking ability (6–9). Exercise therapy is provided by physical therapists. Exercise therapy is reported to be effective in patients with OA of the hip (8). Both manual therapy and exercise therapy are frequently applied in OA of the hip. It is not known which of these approaches is superior. Therefore, the objective of the present randomized clinical trial was to compare the effects of manual therapy and exercise therapy in OA of the hip. PATIENTS AND METHODSStudy participants. During the period September 1. December 2. 00. 1, patients with OA of the hip were referred by orthopedic surgeons or rheumatologists to the outpatient clinic of the physical therapy department with complaints due to OA of the hip. Hip OA was defined according to the clinical criteria of the American College of Rheumatology (1. These criteria are hip pain and < 1. Assessment of the criteria was performed by the referring physician. Exclusion criteria were 1) symptoms in both hips, 2) fear of manipulative therapy, 3) age < 6. Dutch language to complete instructions and forms. The study was approved by the medical ethics committee of the hospital and all participants provided written informed consent. The study was designed as a single- blind, randomized clinical trial and reported following the CONSORT statement for reporting the results of clinical trials (1. Randomization. After inclusion in the trial, radiographs of the hip were taken and scored by a radiologist following a standardized procedure according to a modified Kellgren/Lawrence scale (1. To optimize prognostic similarity, prestratification was conducted for radiographic severity. Two strata were constructed: stratum 1, Kellgren/Lawrence score . Permutated blocks were used to optimize equal distribution of patients between the 2 intervention groups. A random sequence of permutated blocks of 6 envelopes was generated by using random number tables. Treatment and measurements. Treatment started within 1 week of baseline. All patients received treatment at the outpatient clinic for physical therapy of the hospital. At baseline, all participants completed a questionnaire containing questions on demographic variables, previous complaints, duration of symptoms, cointerventions, and previous treatment with exercise therapy or manual therapy. The use of medication and other treatment was recorded at each assessment. Measurements were performed at baseline (week 0), after the treatment period (week 5), and after 3 months (week 1. General improvement experienced by the patient was assessed only at the 5- week followup visit. This was done because we believe that this measure, due to the long period between the followup measurements (1. The use of nonsteroidal antiinflammatory drugs and pain medication prior to the trial was allowed if it was left unchanged during the study period. Other treatment by health professionals, such as occupational therapists, was to be avoided. Blinding. A single assessor (HLH), who was blinded to the allocation of treatment programs, carried out all measurements. Patients were instructed by a secretary not to give information about the allocated treatment to the assessor. Furthermore, the assessor was not allowed to visit the physical therapy department during treatment hours to further assure blinding. Also, all measurements were performed at a location separate from the physical therapy department, on a different floor of the hospital. Finally, the assessor was asked to guess the assigned treatment directly after posttreatment measurements (5 weeks). Interventions. Three manual therapists and 3 physical therapists performed all treatments. The manual therapists were licensed manual therapists. The physical therapists did not receive training in manual therapy or in manipulation techniques. All participating physical therapists were instructed in training sessions. These training sessions were repeated every 3 months. All patients were treated twice weekly for a period of 5 weeks with a total of 9 treatments. The first treatment session was used to tailor the treatment protocol to the individual patient. Content of treatment, deviations from the protocol, and compliance were registered. In addition, adverse effects were registered. Each manual therapy session started with stretching techniques of identified shortened muscles surrounding the hip joint (Appendix A). Second, traction of the hip joint was performed, followed by traction manipulation in each limited position (a high velocity thrust technique) (1. All manipulations were repeated during each session until the manual therapist concluded optimal results of the session. Both manual therapists working at the hospital and experts in the field of manual therapy were involved in developing the treatment protocol. In the exercise treatment group, an exercise therapy program was planned by the physical therapist and adjusted to individual symptoms (Appendix B). Exercise therapy included exercises for muscle functions, muscle length, joint mobility, pain relief, and walking ability. Finally, instructions for home exercises were given. The exercise therapy program was an adaptation of the exercise therapy program of Van Baar et al (8, 9). Outcome assessment. The primary outcome measure, general improvement experienced by the patient, was assessed using a 6- point Likert scale ranging from “much worse” to “complete recovery.” This method is often applied as a primary outcome measure in our area of research and has shown to be a valid and reliable assessment (1. Health- related quality of life was assessed using the Short Form 3. SF- 3. 6) (1. 6). We selected the SF- 3. Hip function was evaluated using the Harris Hip Score and by a walking test (1. The Harris Hip Score is a disease- specific index containing 8 items (2. Items represent pain, walking function, activities of daily living, and range of motion of the hip joint. Walking ability was assessed using a walking test. This test was set out in a corridor of the hospital with a marked distance of 1. Total walking distance was 8. Patients were instructed to walk fast, but not to run. Time to complete the test was recorded (walking speed). At baseline, all patients were asked to formulate his or her main complaint. The patient then rated the intensity of the main complaint on a visual analog scale (VAS). Also, starting stiffness and pain during the walking test were recorded on a VAS (1. Range of hip joint motion from flexion to extension and from internal to external rotation was recorded with a long- legged goniometer according to a standardized procedure (2. Statistical analysis. The target sample size was 1. This number yields a power of 9. Enrollment stopped at 1. The intervention was considered successful if a patient reported to be improved, much improved, or free of complaints. Analyses were performed according to the intention- to- treat principle (2. In addition, a per- protocol analysis was performed excluding patients who had received total hip arthroplasty during the followup period between 5 and 2. At first, data of the 2 groups were screened for normal distribution using normal plots. Comparison between groups was made for age, sex, severity of OA, duration of complaints, and function (Harris Hip Score). To test between groups on the dichotomized primary outcome measure general improvement, odds ratios (ORs) were calculated. For all continuous variables, analyses were performed with analysis of covariance using the baseline scores as the covariate (with 9. In addition, effect sizes were calculated by taking the mean differences of the change scores of the intervention groups and dividing it by the standard deviation of the actual scores of the total population. An effect size of 0. RESULTSComparability. In total, 1. 09 patients were included in the study. The 2 groups were generally similar for baseline characteristics (Table 1); no relevant differences were found. Mean age was relatively high (7. Most patients (8. Kellgren/Lawrence score of 2 or 3, indicating moderate to severe OA. Table 1. Baseline characteristics (n = 1. Total no. Of the 1. After 5 weeks, 6 patients were lost to followup. After 1. 7 weeks, another 9 patients were lost to followup. At 2. 9 weeks, at total of 2. Patient flow and followup. MT = manual therapy; ET = exercise therapy. Compliance, cointerventions, and adverse effects. Patients who prematurely discontinued the treatment programs were denoted as noncompliant. Seven patients were considered noncompliant: 3 in the exercise program and 4 in the manual therapy program. In the exercise program, 1 patient withdrew before the first treatment because of traveling distance to the hospital, 2 patients withdrew due to increase of complaints, and 1 patient discontinued because of cardiorespiratory disease. 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